Introduction To Pharmacokinetics

IV Bolus Dosing - AUC

A patient is given a 100 mg dose of a drug via a single intravenous bolus.

You now know the following:
t1/2 = 4 hours k = 0.173 h-1

What is the area under the concentration-time curve (AUC) of the drug?

Type in your answer to three decimal places then press the OK button.

AUC is: mgxh/L

Time (h)	Plasma Drug Concentration (mg/L)
0	3.3
1	2.8
2	2.4
3	2.0
4	1.7
5	1.4
6	1.2
7	1.0
8	0.8
10	0.6
12	0.4
16	0.2
20	0.1