Introduction To Pharmacokinetics
IV Bolus Dosing - Alternative Vd
t1/2 = 4 hours
k = 0.173 h-1
AUC = 19.328 mgxh/L CL = 5.174 L/h
AUC = 19.328 mgxh/L CL = 5.174 L/h
An alternative equation that you can use to find volume of distribution is shown below.
Using this equation, what is the drug's volume of distribution? (Answer to one decimal place).
The volume of distribution is:
L
| Time (h) | Plasma Drug Concentration (mg/L) |
|---|---|
| 0 | 3.3 |
| 1 | 2.8 |
| 2 | 2.4 |
| 3 | 2.0 |
| 4 | 1.7 |
| 5 | 1.4 |
| 6 | 1.2 |
| 7 | 1.0 |
| 8 | 0.8 |
| 10 | 0.6 |
| 12 | 0.4 |
| 16 | 0.2 |
| 20 | 0.1 |