Introduction To Pharmacokinetics

IV Bolus Dosing - Summary

A patient is given a 100 mg dose of a drug via a single intravenous bolus and the concentration- time data is collected.

SUMMARY

You have finished calculating the parameters.

Using information from the graph across, you were able to calculate the following parameters:

t1/2 = 4 hours
k = 0.173 h-1
AUC = 19.328 mgxh/L
CL = 5.174 L/h
Vd = 29.9 L
(or using a slightly different method, 30.3 L)

Click here to have a final quick look at
the methods and equations used.

Time (h) Plasma Drug Concentration (mg/L)
03.3
12.8
22.4
32.0
41.7
51.4
61.2
71.0
80.8
100.6
120.4
160.2
200.1
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