Introduction To Pharmacokinetics
IV Bolus Dosing Exercise
PLASMA DRUG CONCENTRATION EQUATION
At any time, the plasma drug concentration following administration by a single IV bolus is given by the equation below. Once you have found the parameters you can use this equation to calculate the plasma drug concentration at time t.
Dose = 100 mg
t1/2 = 4 hours
k = 0.173 h-1
AUC = 19.328 mgxh/L
CL = 5.174 L/h
Vd = 29.9 L
Example Question: What was the plasma concentration at 8.5 hours?
Type in your answer to two decimal places then press the OK button.
The plasma concentration was:
mg/L