Introduction To Pharmacokinetics

IV Bolus Dosing - k

A patient is given a 100 mg dose of a drug via a single intravenous bolus.
You now know the following:
Elimination half-life (t1/2) = 4 hours
Now you know the elimination half-life, what is the elimination rate constant (k) of the drug?
Type in your answer to three decimal places then press the OK button.
The elimination rate constant is:   h-1
Hint/Equation
Time (h) Plasma Drug Concentration (mg/L)
03.3
12.8
22.4
32.0
41.7
51.4
61.2
71.0
80.8
100.6
120.4
160.2
200.1
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