Pharmacokinetics Simulations

Elimination Rate Constant

OBSERVATIONS

The larger the elimination rate constant, the faster the rate of drug elimination, leading to lower plasma concentrations.

As the elimination rate constant increases, the rate of decrease of plasma drug concentration also increases (the drug clears the systemic circulation more and more quickly as the elimination rate increases).

You can see this on the semilog graph across: as the elimination rate constant increases, the slope of the graph becomes steeper.

Changes In Elimination Rate Constant
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