INTRODUCTION

In this activity, you will be able to see how changes in the elimination rate constant (k) affect plasma drug concentration levels over time. The model used for the simulation is that of one compartment: single IV bolus dose.

Page 2 shows the pharmacokinetic model for this simulation (also available by clicking on the option at the bottom left called "Pharmacokinetic Model"). The equations used are also available - click on "Equations" at the bottom left.

Page 3 provides instructions for the simulation and page 4 covers the simulation itself. Results can be plotted either on a linear scale or on a semilog scale.