Pharmacokinetics Simulations

Single Oral Dose - Changing The Absorption Rate Constant

OBSERVATIONS

The larger the absorption rate constant, the faster the rate of drug absorption, leading to higher plasma concentrations.

As absorption rate increases, there are several effects:

  • The peak plasma concentration increases.
  • The time to reach the peak plasma concentration decreases (ie the peak plasma concentration occurs earlier).
Changes In Absorption Rate Constant