Flowchart
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The flowchart below shows the process of the laboratory investigation.

Click the Continue button to proceed through the process.

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Sources of Error

There are several sources of error for the dissolution test including those below. Each of these sources should be checked when performing failure investigation.

Click the blue phrases for information. Note: greater detail about each of these sources of error is available in the section 'Critical Physical Parameters'.

The Media
Errors that are due to faulty media preparation can be corrected simply by following the correct procedure required to make the batch of media required for the test.

Failure Investigation

A supervisor should conduct a rudimentary investigation between each sample test to ensure that the calculations were correct (eg. the sample preparation should be reviewed, the standard preparation checked and the spectrophotometer results evaluated to ensure that there were no obstructions in the cell during reading. It is for this reason that all samples are saved and not discarded after testing).
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Investigation is also used to highlight any problems that might have occurred in the dissolution test (eg. there might be a calculation error in test 1 which would cause errors in test 2 calculations and would not otherwise be discovered). It is best to perform each investigation early to verify each step.
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