Analyzed Profiles
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For dissolution tests where profiles are analyzed, changes in volume may occur during the run. Analyte may also be removed throughout the test.

Calculations must therefore account for any volume adjustments and removed analyte that may occur while performing the dissolution test.

Speadsheets used in performing these calculations may be found in the 'Reference Information' chapter of this training course.

Analyzed Profiles
Back

For dissolution tests where profiles are analyzed, changes in volume may occur during the run. Analyte may also be removed throughout the test.

Calculations must therefore account for any volume adjustments and removed analyte that may occur while performing the dissolution test.

Speadsheets used in performing these calculations may be found in the 'Reference Information' chapter of this training course.

Calculating the Sample Concentration

The sample concentration will be calculated against a reference standard of known concentration. The result in % label claim will be compared to acceptable ranges stated in the dissolution method or monograph.

The following calculation provides results in % label claim (%LC).

Move the cursor over the blue elements of the calculation for a description.

Once analyzed, dissolution samples are calculated to determine the amount dissolved (mg) and/or the percent of the labeled amount of active drug substance dissolved in solution.

Analyzed Profiles