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Pharmacokinetic Simulations

Summary

The primary objective of this package is to teach the basic principles of pharmacokinetics through computer simulations. Simulation of the plasma concentration-time profile is a valuable tool to understand the basic pharmokinetic principles and to appreciate the interplay of various pharmokinetic parameters. The program allows the student to evaluate the impact of changing one or more of then pharmokinetic parameters on the concentration-time profile of the drug.

The program covers: iv bolus and oral drug administration; constant rate and intermittent iv infusions; single and multiple drug administration; linear and non-linear drug elimination; one- and two-compartment pharmokinetic models.

Contents

1 Introduction

2 Simulation Examples

Single Oral Dose
Multiple Oral Dose
IV Infusion
Nonlinear Eliminaton
Two Compartment Model

3 Simulations

I: Introduction to Pharmokinetic Parameters

Elimination Rate Constant (k)
Volume of Distribution (Vd)
Half Life (t1/2)
Total Body Clearance (TBC)
Area Under the Concentration-Time Curve
Bioavailability (F)
First-Order Absorption Rate Constant (ka)
Dose (D)

II: IV Bolus Administration

One Compartment Model:
- Single Dose
- Multiple Doses
- Loading Dose and Multiple Doses
Two Compartment Model:
- Single Dose
- Multiple Doses
- Loading Dose and Multiple Doses

III: Oral Administration

One Compartment Model:
- Single Dose
- Multiple Doses
- Loading Dose and Multiple Doses
Two Compartment Model:
- Single Dose
- Multiple Doses
- Loading Dose and Multiple Doses

IV: Multiple Administration

One Compartment Model:
- Multiple IV Doses
- Multiple Oral Doses
Two Compartment Model:
- Multiple IV Doses
- Multiple Oral Doses
- Multiple IV Doses and MM Elimination
- Multiple Oral Doses and MM Elimination

V: Constant Rate IV Infusion

One Compartment Model
- IV Infusion
- Loading Dose and Iv Infusion
Two Compartment Mode
- IV Infusion
- Loading Dose and IV Infusion

VI: Intermittent IV Infusion

One Compartment Model:
- Single IV Infusion
- Multiple Short IV Infusions
- Loading Dose and Multiple IV Infusions
Two Compartment Model:
- Single IV Infusion
- Multiple Short IV Infusions
- Loading Dose and Multiple IV Infusion

VII: Multiple Compartments

Two Compartment Model:
- Single IV Dose
- Multiple IV Doses
- Single Oral Dose
- Multiple Oral Doses
- IV Infusion
- Loading Dose and IV Infusion
- Single IV Dose
Central and Peripheral Profiles
- Multiple IV Doses - Central and Peripheral Profiles

VIII: Nonlinear Elimination

Single IV Dose - Nonlinear Elimination
Multiple IV Doses - Nonlinear Elimination
Single Oral Dose - Nonlinear Elimination
Multiple Oral Doses - Nonlinear Elimination
MM Elimination In Presence of a Competitive Inhibitor

Pharmacokinetic Simulations

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