Pharmacokinetics Simulations

Two Compartment Model: Single IV Bolus Dose

The following shows the pharmacokinetic model for a single IV bolus dose - for a two compartment model.

Legend

Dose (D)

is the administered dose, mg

is the volume of distribution of the central compartment, litres

k12

is the first order transfer rate constant from the central to the peripheral compartment, hour-1

k21

is the first order transfer rate constant from the peripheral to the central compartment, hour-1

k10

is the first order elimination rate constant from the central compartment, hour-1