Antagonists: Comparing Dose-Response Curves

Relative Strengths

You can roughly gauge the relative strengths of reversible competitive antagonists by looking at their dose-response curves and seeing how far to the right each of the antagonists shifts the curve for a particular concentration of the antagonist. The greater the shift for a particular concentration, the stronger the antagonist. Click on the areas below to see what happens to the dose-response curves as pA2 varies.